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Author Prasong Koonanuwatchaidet
TitleChemically occurring N-Nitrosodimethylamine in Thai fermented fishes is mutagenic salmonella tester strains
ImprintSingapore : Singapore Institute of Food Science
Call# T990277

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JournalProceedings of the 6th ASEAN Food Conference. Raffles City Convention Centre, Westin Stamford
AbstractPartially purified N-Nitrosodimethylamine (NDMA)from 88 samples of uncooked fermented fish extracts obtaining from three different geographical regions of Thailand was quantitatively investigated using absorption spectrophotometric technique. Only about 7.56% of total specimens observed to be negative for this particular toxic compound. The NDMA levels of positive batches were in the range of 32 upto 638 parts per billion (ppb), 28 upto 352 ppb, and 42 upto 1,228 ppb for the samples obtained from Northern area, Central area and Northeastern part of Thailand, respectively. The in vitro mutagenesis activity of chemically occurring NDMA in all positive batches were also detected by using two different strains of Salmonella typhimurium (TA 98 and TA 100)via preincubation with a rat liver microsomal enzyme system. The number of revertant colonies of TA 100 strain which exhibited the base-pair substitution mutation was markedly higher than that of TA 98 strain. The mutagenicity of fermented fish extracts obtained from Northern and Central regions. The findings in this communication reveal that the general correlationship between levels of NDMA and its mutagenic activity of their corresponding extracts seems to be fairly well.
Descript776 p. ; 749-758
NoteTP368.A83 1997
SubjectN-Nitrosodimethylamine
Fermented fish--analysis
Salmonella
Mutagenic activity
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