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Author Jinnawat Manasathien
Alternative Author Piyanut Khanema
Suranaree Journal of Science and Technology
TitleAntioxidant and Cytotoxic Activities of Mangosteen (Garcinia Mangostana) Pericarp Extracts
ImprintVol. 22 No. 4, October-December 2015
Call# FOOD 7688

CALL # Volume Number Month Year Barcode Status

AbstractThia study was designed to evaluate the total phenolic compounds (TPC), antioxidation, antiproliferation, and apoptotic properties of mangosteen (Garcinia mangostana L.) pericarp ethanolic and water extracts (MPE/e and MPE/w) using the human breast adenocarcinoma cell line, MCF-7, as a model system, The Folin-Ciocalteu method was used for the TPC investigation and DPPH radical scavenging activity and the ferric reducing antioxidant power (FRAP) was used for the antioxidant properties. Cell viability was evalluated by esazurin and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assays for 12 and 24 h. The study found that the TPC of the MPE/e were more than those of the MPE/w (119.95 ? 1.03> 84.40 ? 0.29 ug/ml, respectively, Moreover, only the MPE/e was expressedas a partial inhibitor on the proliferation of MCF-7 cells in a dose-and time-dependent manner. The MPE/e was a strongly positive influence on the antiproliferation and apoptotic induction of the MCF-7 cell, as seen via the morphological changes and oligonucleosomal DNA fragments. In conclusion,the MPE/e may be proposed to develop into cytotoxic or antitumor agents, if it has been investigated that it is effective and non-toxic to the normal cells of anmicals and humans.
DescriptPage 357-367
SubjectMangosteen
antioxidant activity
antiproliferation
apoptosis
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