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Author Nisaudah Radenahmad
Alternative Author Winyou Mitranun
Kitja Sawangjaroen
Ibrahim Sayoh
Songklanakarin Journal of Science and Technology
TitleBeneficial effects of young coconut juice feeding on the lipid, renal and liver profiles, in ovariectomized rats: Preliminary novel findings
ImprintVol. 38 No. 1, January-February 2016
Call# FOOD 7771

CALL # Volume Number Month Year Barcode Status

AbstractThe purpose of this study was to determine the effects of feeding young coconut juice (YCJ), known t o contain ? - sitosterol, to ovariectomized rats, a model for postmenopausal women, on the lipid, renal and liver metabolism profiles. Four groups of female rats (6 in each group) were included in this study. These included sham-operated, o variectomized (ovx), ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. A t the end of the third and the fourth week of study, the rats were sacrificed and their serum estradiol (E2) was analyzed. The uterus was removed along with the kidney and liver. The latter was paraffin processed for histopathological assessment. In co ntast with the 7 days treatments, all parameters of the 14 days treatment had improved. After 14 days of treatment, the ci rculating levels of BUN, creatinine, cholesterol, triglyceride, LDL, AST, ALT, ALP, total protein and albumin of ovx+YCJ grou p were not significantly different from the sham and ovx groups. Only the serum HDL level of the ovx+YCJ group was significan tly higher than that of the sham group. The histopathological assessment of the liver and kidney showed no significant ch anges when compared with the control groups. Glycogen accumulation appeared in the cytoplasm of the hepatocytes particul arly in the ovx+YCJ group but significant changes of the hepatocytes containing glycogen were not detected. No other abn ormal features were seen in any of the four groups. The %age uterine/body weights indicated that YCJ feeding in ovx rats at 100 mL/kgBW for up to two weeks did not cause increased uterine weight. In summary, this study confirmed that feedi ng YCJ had beneficial effects on the serum lipid profile, and maintained liver and renal functions for up to 2 weeks after administration.
DescriptPage 57-65
Subjectyoung coconut juice